Robust Proton Treatment Planning: Physical and Biological Optimization

Recent Advances in Intensity Modulated Proton Therapy Treatment Planning Optimization

Radiation therapy is a non-invasive treatment modality for cancer patients. Radiation therapy treatment planning for cancer patients provides many challenging optimization problems. Various variables of a treatment plan need to be optimized so that the resulting plan can kill all cancerous cells while minimizing damage on the patient’s normal tissues. Intensity modulated proton therapy (IMPT) h...

Integrated planning for blood platelet production: a robust optimization approach

Perishability of blood products as well as uncertainty in demand amounts complicate the management of blood supply for blood centers. This paper addresses a mixed-integer linear programming model for blood platelets production planning while integrating the processes of blood collection as well as production/testing, inventory control and distribution. Whole blood-derived production methods for...

A critical evaluation of worst case optimization methods for robust intensity-modulated proton therapy planning.

PURPOSE To critically evaluate and compare three worst case optimization methods that have been previously employed to generate intensity-modulated proton therapy treatment plans that are robust against systematic errors. The goal of the evaluation is to identify circumstances when the methods behave differently and to describe the mechanism behind the differences when they occur. METHODS The...

Comparative Treatment Planning in Radiotherapy and Clinical Impact of Proton Relative Biological Effectiveness

Investigation of physical penumbra definition in treatment planning

Background: Due to the small size of the beamlets in IMRT (intensity modulated radiotherapy), physical penumbra is one of the important dosimetric parameters and small changes in the penumbra have a notable impact on the results. The physical penumbra width is defined as the lateral distance between two specified isodose curves at a specified depth of phantom. In this study, after demonstrating...